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| The Big Bang Theory Season 4 : |
| This season the Big Bang gang’s romantic universe expands. On the rebound from Penny Leonard falls into the arms of Raj’s sister Priya. Sheldon gets a girlfriend or rather a friend who is a girl: Amy a dour neurobiologist who declares herself besties with Penny. Howard and Bernadette heat up. And so do Raj and Bernadette (at least in Raj’s Bollywood daydream). |
| Episode 1 - [The Robotic Manipulation] |
| Details : Penny tags along on Sheldon's first ever date; Wolowitz finds a new use for a robotic arm. |
| Guest Cast and Crew : Vernee Watson-Johnson as Althea | Carol Ann Susi as Debbie Wolowitz (voice) | Mayim Bialik as Amy Fowler | |
| Air Date : Sep. 23, 2010 | Rating ➦ ★★★★★★★ |
| Episode 2 - [The Cruciferous Vegetable Amplification] |
| Details : Realizing he will not live long enough to download his consciousness into a robot body Sheldon tries to extend his life span. |
| Guest Cast and Crew : Steve Wozniak as Himself | |
| Air Date : Sep. 30, 2010 | Rating ➦ ★★★★★★★ |
| Episode 3 - [The Zazzy Substitution] |
| Details : The guys are concerned as Sheldon searches for an alternative to human companionship. |
| Guest Cast and Crew : Laurie Metcalf as Mary Cooper | Mayim Bialik as Amy Fowler | |
| Air Date : Oct. 07, 2010 | Rating ➦ ★★★★★★★ |
| Episode 4 - [The Hot Troll Deviation] |
| Details : An embarrassing secret of Wolowitz's comes to light while Sheldon and Raj have a small war at work. |
| Guest Cast and Crew : George Takei as Himself | Carol Ann Susi as Debbie Wolowitz (voice) | Katee Sackhoff as Herself | Melissa Rauch as Bernadette Rostenkowski | |
| Air Date : Oct. 14, 2010 | Rating ➦ ★★★★★★★ |
| Episode 5 - [The Desperation Emanation] |
| Details : Leonard realizes he’s the only one without a girlfriend while Sheldon wants to get rid of his. |
| Guest Cast and Crew : Carol Ann Susi as Debbie Wolowitz (voice) | Annie O'Donnell as Mrs. Fowler | Charlotte Newhouse as Joy | Kevin Sussman as Stuart Bloom | Melissa Rauch as Bernadette Rostenkowski | Mayim Bialik as Amy Fowler | |
| Air Date : Oct. 21, 2010 | Rating ➦ ★★★★★★ |
| Episode 6 - [The Irish Pub Formulation] |
| Details : Leonard keeps an affair a secret from Sheldon Howard and Raj. |
| Guest Cast and Crew : Aarti Mann as Priya Koothrappali | |
| Air Date : Oct. 28, 2010 | Rating ➦ ★★★★★★ |
| Episode 7 - [The Apology Insufficiency] |
| Details : Sheldon's answers during an FBI interview put Wolowitz's security clearance in jeopardy. |
| Guest Cast and Crew : Eliza Dushku as Angela Page | Neil deGrasse Tyson as Himself | |
| Air Date : Nov. 04, 2010 | Rating ➦ ★★★★★★★ |
| Episode 8 - [The 21-Second Excitation] |
| Details : While the guys camp in line for a long-awaited movie screening Penny and Bernadette invite Amy to her first slumber party. |
| Guest Cast and Crew : Eric André as Joey | Wil Wheaton as Himself | Melissa Rauch as Bernadette Rostenkowski | Mayim Bialik as Amy Fowler | |
| Air Date : Nov. 11, 2010 | Rating ➦ ★★★★★★★ |
| Episode 9 - [The Boyfriend Complexity] |
| Details : Penny asks Leonard to lie to her father while Howard Raj and Bernadette pull an all-nighter at a telescope. |
| Guest Cast and Crew : Keith Carradine as Wyatt | Melissa Rauch as Bernadette Rostenkowski | |
| Air Date : Nov. 18, 2010 | Rating ➦ ★★★★★★★ |
| Episode 10 - [The Alien Parasite Hypothesis] |
| Details : Amy finds she has sexual feelings for Penny's ex while Koothrappali and Wolowitz try to prove who would be the better superhero. |
| Guest Cast and Crew : Brian Thomas Smith as Zack Johnson | Melissa Rauch as Bernadette Rostenkowski | Mayim Bialik as Amy Fowler | |
| Air Date : Dec. 09, 2010 | Rating ➦ ★★★★★★★ |
| Episode 11 - [The Justice League Recombination] |
| Details : The guys find a super use for Penny's new boyfriend Zack when they enter a costume contest as the Justice League. |
| Guest Cast and Crew : Brian Thomas Smith as Zack Johnson | Kevin Sussman as Stuart Bloom | |
| Air Date : Dec. 16, 2010 | Rating ➦ ★★★★★★★ |
| Episode 12 - [The Bus Pants Utilization] |
| Details : Leonard's idea for a smartphone app derails his friendship with Sheldon. |
| Air Date : Jan. 06, 2011 | Rating ➦ ★★★★★★★ |
| Episode 13 - [The Love Car Displacement] |
| Details : Bernadette runs into her ex-boyfriend while attending a science event with Wolowitz. |
| Guest Cast and Crew : Rick Fox as Glenn | Ed Lieberman as Announcer (voice) | Melissa Rauch as Bernadette Rostenkowski | Mayim Bialik as Amy Fowler | |
| Air Date : Jan. 20, 2011 | Rating ➦ ★★★★★★★ |
| Episode 14 - [The Thespian Catalyst] |
| Details : Hoping it will make him a better teacher Sheldon has Penny give him acting lessons. Raj has fantasies about a friend's girlfriend. |
| Guest Cast and Crew : Melissa Rauch as Bernadette Rostenkowski | Mayim Bialik as Amy Fowler | Executive Producer : Steven Molaro | |
| Air Date : Feb. 03, 2011 | Rating ➦ ★★★★★★ |
| Episode 15 - [The Benefactor Factor] |
| Details : A wealthy donor to the university makes Leonard consider how far he's willing to go for the sake of science. |
| Guest Cast and Crew : Jessica Walter as Mrs. Latham | Joshua Malina as President Siebert | Mayim Bialik as Amy Fowler | Executive Producer : Steven Molaro | |
| Air Date : Feb. 10, 2011 | Rating ➦ ★★★★★★★ |
| Episode 16 - [The Cohabitation Formulation] |
| Details : As Wolowitz contemplates taking things with Bernadette to the next level Leonard rekindles his relationship with Raj's sister. |
| Guest Cast and Crew : Aarti Mann as Priya Koothrappali | Carol Ann Susi as Debbie Wolowitz (voice) | Melissa Rauch as Bernadette Rostenkowski | Mayim Bialik as Amy Fowler | Executive Producer : Steven Molaro | |
| Air Date : Feb. 17, 2011 | Rating ➦ ★★★★★★ |
| Episode 17 - [The Toast Derivation] |
| Details : Sheldon becomes concerned when everybody begins to hang out at Raj's apartment and discovers Leonard is the center of the group. |
| Guest Cast and Crew : LeVar Burton as Himself | Aarti Mann as Priya Koothrappali | Brian Thomas Smith as Zack Johnson | John Ross Bowie as Barry Kripke | Kevin Sussman as Stuart Bloom | Melissa Rauch as Bernadette Rostenkowski | Mayim Bialik as Amy Fowler | Executive Producer : Steven Molaro | |
| Air Date : Feb. 24, 2011 | Rating ➦ ★★★★★★★ |
| Episode 18 - [The Prestidigitation Approximation] |
| Details : Sheldon is baffled by Wolowitz's magic trick. Meanwhile Leonard realizes dating Priya may make it impossible to continue being friends with Penny. |
| Guest Cast and Crew : Aarti Mann as Priya Koothrappali | Executive Producer : Steven Molaro | |
| Air Date : Mar. 10, 2011 | Rating ➦ ★★★★★★ |
| Episode 19 - [The Zarnecki Incursion] |
| Details : Sheldon's online-game account is hacked by Todd Zarnecki who then proceeds to steal all his items prompting the guys to go on a quest to retrieve them. Penny Bernadette and Amy discuss how Penny groomed Leonard to be willing to try various things and more adventurous boyfriend... for some other woman — Priya. |
| Guest Cast and Crew : Aarti Mann as Priya Koothrappali | Carol Ann Susi as Debbie Wolowitz (voice) | Lanny Joon as Officer Shin | Chris Reed as Todd Zarnecki | Melissa Rauch as Bernadette Rostenkowski | Mayim Bialik as Amy Fowler | Executive Producer : Steven Molaro | |
| Air Date : Mar. 31, 2011 | Rating ➦ ★★★★★★ |
| Episode 20 - [The Herb Garden Germination] |
| Details : Sheldon and Amy decide to start several rumors about the others as a test. Meanwhile Howard takes his relationship with Bernadette to even higher level. |
| Guest Cast and Crew : Alice Amter as Mrs. Koothrappali | Aarti Mann as Priya Koothrappali | Brian Greene as Himself | Brian George as V.M. Koothrappali | Melissa Rauch as Bernadette Rostenkowski | Mayim Bialik as Amy Fowler | Executive Producer : Steven Molaro | |
| Air Date : Apr. 07, 2011 | Rating ➦ ★★★★★★★ |
| Episode 21 - [The Agreement Dissection] |
| Details : When Leonard spends too much time in the shower with Priya Sheldon charges Leonard with two violations of the roommate agreement. However before he can get too far Priya uses her skills as a lawyer to nullify the charges due to the agreement's vague wording much to Sheldon's dismay. When the guys take advantage of Priya's skills in order to eat Greek food on pizza night Sheldon goes to Penny who invites him to a girls' night out with Amy and Bernadette which Sheldon agrees to after Penny mentions that they may be talking trash about Priya. After the girls drink some cocktails they decide to take Sheldon dancing which Sheldon reluctantly goes along with. After dancing Sheldon takes an intoxicated Amy back to her apartment and as well as talking about Priya meets a monkey who is addicted to smoking cigarettes. Amy tells Sheldon not to give in to Priya's law skills before kissing him and going to her bathroom to vomit. |
| Guest Cast and Crew : Aarti Mann as Priya Koothrappali | Arnold Chun as Ho-Jun | Tom Yi as Dispatcher (voice) | Melissa Rauch as Bernadette Rostenkowski | Mayim Bialik as Amy Fowler | Executive Producer : Steven Molaro | |
| Air Date : Apr. 28, 2011 | Rating ➦ ★★★★★★★ |
| Episode 22 - [The Wildebeest Implementation] |
| Details : Raj attempts to cure his social anxiety disorder while Penny uses Bernadette to spy on Leonard and his girlfriend. |
| Guest Cast and Crew : Aarti Mann as Priya Koothrappali | Tiffany Dupont as Angela | Whitney Avalon as Elsie | Melissa Rauch as Bernadette Rostenkowski | Mayim Bialik as Amy Fowler | Executive Producer : Steven Molaro | |
| Air Date : May. 05, 2011 | Rating ➦ ★★★★★★ |
| Episode 23 - [The Engagement Reaction] |
| Details : When Howard finally breaks the news to his mom that he's engaged to Bernadette it lands her in the hospital. |
| Guest Cast and Crew : Aarti Mann as Priya Koothrappali | Phil Abrams as Dr. Bernstein | Carol Ann Susi as Debbie Wolowitz (voice) | Sharon Omi as Nurse in Biohazard Suit | Melissa Rauch as Bernadette Rostenkowski | Executive Producer : Steven Molaro | |
| Air Date : May. 12, 2011 | Rating ➦ ★★★★★★★ |
| Episode 24 - [The Roommate Transmogrification] |
| Details : When Bernadette receives her PhD Wolowitz feels emasculated. Raj and Leonard swap places and Penny does something she's regrets. |
| Guest Cast and Crew : Alice Amter as Mrs. Koothrappali | Aarti Mann as Priya Koothrappali | Carol Ann Susi as Debbie Wolowitz (voice) | Brian George as V.M. Koothrappali | Melissa Rauch as Bernadette Rostenkowski | Mayim Bialik as Amy Fowler | Executive Producer : Steven Molaro | |
| Air Date : May. 19, 2011 | Rating ➦ ★★★★★★★ |